Every cell in the human body faces a chronic challenge: protecting its DNA. Whenever cells divide, their genetic material ...

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

A new multi-omics framework proposes that tumor immunogenicity emerges only when epigenetic permissiveness, DNA damage ...

The world’s oldest land animal carries 287 unique gene variants involved in DNA repair and other defenses against aging, ...

A team of scientists in Norway has found evidence for a new mechanism for the development of cancer in children: They seem to ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. The publication of two papers ...

Repair of damaged DNA is a complex process, particularly when it is compacted into nucleosomes. There are a number of genetic ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

Researchers have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging. Researchers at ...