An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Molecular-Level Dissection ...

Whole-genomic sequencing has revolutionized the amount and detail of genetic diversity now available to researchers to study. While the researchers previously had looked at a few hundred mobile ...

The human genome, an intricate tapestry of genetic information for life, has proven to be a treasure trove of strange features. Among them are segments of DNA that can "jump around" and move within ...

Around 2015, Katherine Chiappinelli was investigating the mechanism behind a group of drugs approved to treat blood cancers—and showing promise against other cancers—when she made a puzzling discovery ...

Transposable elements are DNA sequences which are also known as “jumping genes”, given their ability to move from one location of the genome to another. They are present in all eukaryotic genomes and ...

Heterochromatin, sometimes known as the “dark side of the genome,” is a poorly studied fraction of DNA that makes up about half of our genetic material. For more than 50 years scientists have puzzled ...

Ancient viruses are embedded everywhere in the human genome. Estimates range, but it's thought that about eight percent of the human genome could be made up of these ancient retroviruses, which are ...

Retrotransposons are pivotal in human genome evolution, driving structural variation and regulatory innovation while influencing health and disease.

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors ...

New research from scientists at Cleveland Clinic’s Genome Center and their collaborators at other institutions describes a pathway that human herpes simplex-1 (HSV-1) can use to contribute to the ...