Illustration of CAR (chimeric antigen receptor) T cell immunotherapy, a process that is being developed to treat cancer. T cells (blue), part of the body's immune system, are taken from the patient ...

Senescent fibroblasts are aging cells that no longer divide and protect against tumor development. Yet two decades have gone by since cell biologist Judith Campisi, Ph.D., paradoxically demonstrated ...

Senescent cells, often referred to as "zombie" cells, have long been associated with aging and disease. However, a new study from the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden ...

UConn Health and The Jackson Laboratory for Genomic Medicine assume key roles, share in $13.5 million NIH grant with top medical centers Researchers at the UConn Center on Aging at UConn Health and ...

Aging-related physiological decline and the accumulation of senescent or aging cells in bodily tissues can trigger a number of diseases. The removal of senescent cells, also known as "senolysis," can ...

Cancer cells have a series of features that allow the immune system to identify and attack them. However, these same cells create an environment that blocks immune cells and protects the tumor. This ...

These aren’t ghostly eyes of “zombie cells,” a popular name for senescent cells, but are double or triple nuclei, a common characteristic of these cells, glowing with a ramped-up fluorescent tag ...

In the early 2000s, Darren Baker was studying cancer by working with mouse models whose chromosomes failed to segregate properly, a risk factor for tumor formation. One of the strains he created had a ...

Multiple researchers at the Jackson Laboratory (JAX) are taking part in an ambitious research program spanning several top research institutions to study senescent cells. Senescent cells stop dividing ...

Cellular senescence is a process of irreversible cell-cycle arrest in response to various internal or external stressors. In addition to preventing the uncontrolled proliferation of damaged cells, ...

MIT researchers combined Raman microscopy with single-cell and spatial gene-expression measurements to identify biochemical patterns associated with cellular senescence without destroying the tissue ...

As individuals age, the muscles used to walk up stairs and carry groceries gradually weaken, making everyday tasks more difficult. That same decline can happen because of illnesses like muscular ...